Combination Dual-Source CT and CT MPI Increases Diagnostic Yield

Objective: To evaluate combined dual-source coronary CT angiography (CTA) and CT myocardial perfusion imaging (MPI) with dual-source coronary CTA alone using conventional invasive coronary angiography as the reference standard. Design: Prospective study. Participants: 54 patients who had coronary artery disease as seen on dual-source CTA. All patients subsequently underwent adenosine-induced stress dual-energy CT as well as conventional angiography. Methods: The adenosine-induced stress dual-energy CTs were performed in dual-energy mode using the same parameters as the dual-source CTA. Adenosine was given intravenously, and retrospective ECG-gated images were obtained. Evaluation by 2 radiologists was performed as follows: (1) classifying the degree of coronary stenosis using the dual-source CTA; (2) evaluating myocardial perfusion defects using rest and stress MPI with dual-source CTA and adenosine-induced stress dual-energy CT; and (3) reclassifying the severity of coronary stenose more...