Combining ⁶⁸Ga-PSMA Uptake With Prostate MRI Can More Accurately Detect PCa

Background: Although prostate MRI has improved the detection of prostate cancer (PCa) based on biopsy results, approximately 17% of these suspicious MRI lesions yield benign results when biopsied. The results of the PRIMARY trial did not show additive improvement of prostate biopsy results when adding the Gallium-68 prostate-specific membrane antigen ( 68 Ga-PSMA) uptake values with to MRI findings; however, a low maximum standardized uptake value (SUVmax) of 4 was used for the cutoff. Further studies indicate combining a higher level of SUVmax with 68 Ga-PSMA with MRI findings may improve the accuracy of PCa detection. Objective: To determine whether the SUVmax of 68 Ga-PSMA in the prostate when combined with MRI findings, can more accurately predict presence of PCa on biopsy. Design: Single-center cohort study. Methods: Data were obtained for analysis from patients who participated in either retrospective or prospective trials using 68 Ga-PSMA PET/CT and underwent prebiopsy prostat more...