GTR With RT May Improve Survival in Octogenarians With Glioblastoma Multiforme

Background: As life expectancy continues to rise, more and more patients are offered surgical treatments for various pathologies including brain tumor. Treatment of glioblastoma multiforme (GBM) includes surgery, radiotherapy (RT), and chemotherapy (CT) to prolong survival. The efficacy of these treatment modalities in octogenarian patients has yet to be fully assessed in the literature. Objective: To assess survival in patients aged ≥80 years with GBM. Design: Retrospective review of patients identified from the National Cancer Database. Methods: Patients aged >65 years with GBM from 1989 to 2016 were identified. They were stratified into 2 groups. Group1 included patients aged ≥80 years, and group 2 included those aged 65 to 79 years. All available patient demographic characteristics, disease characteristics, and clinical outcomes were collected. Bivariate survival models were created using Kaplan-Meier estimates. A Cox proportional-hazards model was used for final adjusted anal more...