Use of Statins Improves Mortality in Patients With Cirrhosis

Background: When statins first came on the market, there was concern about possible hepatotoxicity. However, subsequent data have mollified this fear. Objective: To assess the effect of statins in patients with cirrhosis. Design: Systematic review. Methods: Included studies enrolled only patients with cirrhosis, included at least 1 group receiving statins as a standalone treatment, and reported ≥1 of the following outcomes: mortality, variceal bleeding, spontaneous bacterial peritonitis (SBP), hepatorenal syndrome (HRS), ascites, hepatic encephalopathy (HE), hepatic venous pressure gradient (HVPG), or hepatocellular carcinoma (HCC). In addition, the study had to include a control group. Three databases were searched: PubMed, Embase, and Cochrane Central Registry of Controlled Trials. No language restrictions were imposed. Data were extracted on a standardized form, and the risks of bias (ROBs) were assessed. Two investigators independently conducted the study selection, data extra more...